DiaGene Study


The DiaGene Study is a project of the Catharina Hospital, Maxima Medical Center, Diagnostic Center Eindhoven and Erasmus MC Rotterdam, The Netherlands.

Mandy van Hoek, Louis Lieverse and Eric Sijbrands

Disorders of carbohydrate and lipid metabolism are important risk factors for cardiovascular disease, which is the leading cause of death in the Western world. Obesity increases susceptibility to type 2 diabetes mellitus and dyslipidemia and the related cardiovascular damage. In our population, the prevalence of obesity is rising markedly. This is the result of a sedentary lifestyle with hypercaloric intake and physical inactivity.


The DiaGene study is a case-control study of patients with type 2 diabetes (n=2,000) and controls (n=1,000) from the Eindhoven population. The mean follow-up is 5 years and the database contains 3-monthly diabetes check-ups. The diagnostic criteria are based on the ADA guidelines (The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2003;26:S5-S20.).


The primary aim of the DiaGene Study is to identify etiologic factors of type 2 diabetes. The study has been added for replication purposes to the DIAGRAM+ consortium. Examples of publications. The secondary aim of the study restricted to the cohort of patients with type 2 diabetes is used to investigate the complications of the disorder.

Currently, we are performing genomics, glycomics and the Lp(a) Ahead Study. Other comics and in depth studies are queueing in our fund applications.

Requests for collaborations or other questions for the MT of the DiaGene Study are welcome through the projects box of the sidebar.